Alpha Lipoic Acid (ALA)

Alpha Lipoic Acid (ALA) - NatrolThe following information is NOT meant to be used to treat yourself or patients

Generic name

  • Alpha Lipoic Acid (ALA)

Brand name

  • Many manufacturers make alpha lipoic acid.
  • Natrol is one brand that is good and easily accessible to patients (sold at Walgreens):  Find it HERE.

Class

  • Antioxidant

MOA

  • Used by mitochondrial enzymes in cells to convert glucose into energy
  • After uptake into cells, it is reduced to dihydrolipoic acid (DHLA)
  • Thought to help with diabetic peripheral neuropathy

Advantages

  • Inexpensive:  $7-10 for fifty 300-mg capsules at Walgreens
  • Safe
  • QuickIn studies, patients noticed a benefit over placebo with their burning, paresthesias, and numbness symptoms by day 5.

Disadvantages

  • As with all supplements, the quality is not controlled by the FDA and therefore differs considerably between manufacturers

Dosing

  • 600-mg daily:  Usually given as 300-mg BID

Adverse Effects

  • Headaches, nausea, vomiting
  • Dose dependent:  Seen more in patients taking 1200-mg a day

Research

  1. Here is a good review article on Alpha Lipoic Acid for diabetic peripheral neuropathy:

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