Baclofen – Lioresal

The following information is NOT meant to be used to treat yourself or patients

• 

  Generic name = Baclofen

• Trade name = Lioresal
  
• Class = muscle relaxant
• MOA
  • Centrally-acting
  • Analog of GABA, but no evidence it works on the GABA system
• Advantages
  • Great for spasticity in spinal cord injured, brain injured, and stroke patients
  • Relatively inexpensive
• Disadvantages
  • Sedation
• Dosing
  • 10, 20-mg pills
  • Starting dose: 5  mg PO tid
  • Titrating: Increase by one 5-mg pill tid every 3 days until desired effect
  • Max dose:  80 mg/day
  • Adequate trial period:  4 weeks
• Note:
  • MUST taper dose to discontinue
  • Renal dosing