Posted on 15 November 2010. Tags: axonotmesis, B6, bilateral, BMI, carpal tunnel release, carpal tunnel syndrome, chiropractic care, corticosteroid, CTR, CTS, depo-medrol, dexamethasone, EMG, endoscopic, entrapment, ergonomic keyboards, females, hypalgesia, iontophoresis, Katz hand diagram, laser acupuncture, magnet therapy, MRI, NCS, needle electromyography, nerve conduction study, neuropathy, neuropraxia, NSAIDs, numbness, obesity, pain, Phalen's test, pregnancy, pregnant women, pyroxidine, shaking hands, thenar atrophy, Tinel's test, tingling, ultrasound, vibratory tools, wrist ratio, wrist splints
By Chris Faubel, MD –
Source: MedicineNet.com
Background
- Carpal tunnel syndrome is a peripheral entrapment mononeuropathy of the median nerve as it courses through the carpal tunnel.
- Local compressive entrapment causes demyelination leading to nerve block (neuropraxia). If the compression persists, local nerve blood flow decreases (vasa nervorum) leading to a cascade of events eventually causing axon damage (axonotmesis).
- The pain is thought to result from inflammatory mediators (TNFα) causing abnormal Na+ influx into these damaged nociceptive fibers.
Epidemiology
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