Posted on 27 March 2012. Tags: anti-inflammatory, etodolac, Lodine
The following information is NOT meant to be used to treat yourself or patients
Generic name= Etodolac
Image from Drugs.com
Trade name = Lodine
Class = anti-inflammatory
MOA
- Blocks cyclooxygenase (COX-1 & COX-2) and thus production of prostaglandins
Dosing
- 200, 300, 400, 500, 600-mg pills
- Typically prescription: 200-400mg TID or QID
- Max dose: Do not exceed 1200-mg/day
Note:
- COX-1 normally produces prostaglandins that are gastroprotective. Thus, blocking it can lead to gastric ulcers/bleeds.
- Take with food or 8-oz of water
- May increase risk of cardiovascular thrombotic events, MI, and stroke
- Consider avoiding in patients with cardiac history
- Absolute contraindication: ASA allergy
- Use with caution in renal and liver impairment
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Posted in Anti-inflammatories, Etodolac - Lodine, Medications, Miscellaneous
Posted on 16 September 2011.
The following information is NOT meant to be used to treat yourself or patients
- Generic name = Ketorolac
Source: buyemp.com
- Trade name = Toradol
- Class = anti-inflammatory
- MOA
- Blocks cyclooxygenase (COX-1 & COX-2) and thus production of prostaglandins
- In vitro, ketorolac is the most COX-1 predominant NSAID (click here)
- Advantages
- When used IM or IV, it is the go-to NSAID for acute relief of severe pain
- Dosing
- Availability: 10-mg pills; 15, 30, 60-mg vials
- Typically given as a one-time IM/IV dose of 60-mg or 30-mg, or multi-dosed as 30-mg IM/IV q6h or 15-mg q6h
- If given as PO route, 10-mg PO q6h
- Max dose: Do not exceed 120-mg IV/IM per day, or 40-mg PO per day
- Max of 5 consecutive days
- Renal insufficiency dosing: 15-mg IV/IM q6h; do not exceed >60-mg/day
- Advanced renal impairment: contraindicated
- Note:
- COX-1 normally produces prostaglandins that are gastroprotective. Thus, blocking it can lead to gastric ulcers/bleeds
- Take with food or 8-oz of water
- May increase risk of cardiovascular thrombotic events, MI, and stroke
- Avoid in patients with cardiac history
- Absolute contraindication: ASA allergy
Related Content:
Posted in Anti-inflammatories, Ketorolac - Toradol, Medications, Miscellaneous
Posted on 21 August 2010. Tags: anti-inflammatory, COX-2, Cyclooxygenase, Inflammation, meloxicam, mobic, pain
The following information is NOT meant to be used to treat yourself or patients.
- Generic name = Meloxicam
- Trade name = Mobic
- Class = anti-inflammatory
- MOA
- Blocks cyclooxygenase (COX-1 & COX-2) and thus production of prostaglandins
- Advantages
- BID dosing
- Inexpensive: On the Target and Wal-Mart $4/month generic lists
- Dosing
- Note:
- COX-1 normally produces prostaglandins that are gastroprotective. Thus, blocking it can lead to gastric ulcers/bleeds
- Take with food or 8-oz of water
- May increase risk of cardiovascular thrombotic events, MI, and stroke
- Avoid in patients with cardiac history
- Absolute contraindications: ASA allergy, gastritis/ulcer, severe hepatic impairment, CABG
Related Content:
Posted in Anti-inflammatories, Medications, Meloxicam - Mobic, Miscellaneous
Posted on 21 August 2010. Tags: arthrotec, diclofenac, flector, gel, Misoprostol, Non-steroidal anti-inflammatory drug, pain, patch, voltaren
The following information is NOT meant to be used to treat yourself or patients
- Generic name = Diclofenac
- Trade name = Voltaren, Voltaren-XR, Voltaren gel, Arthrotec, Flector patch
- Class = anti-inflammatory
- MOA
- Blocks cyclooxygenase (COX-1 & COX-2) and thus production of prostaglandins
- Advantages
- Relatively inexpensive as generic
- Comes in multiple formulations (pills, gel, patch)
- Dosing
- 25, 50, 75-mg tablets
- 100-mg extended release tablet
- 25-mg capsule
- 1% and 3% gel (Voltaren Gel)
- Apply 2-grams (upper extremities) or 4-grams (lower extremities) to painful joint QID [no more than 8 or 16-gram/day to any single joint respectively]
- How to measure and apply the gel
- 1.5% topical solution
- 180-mg patch (Flector patch)
- Note:
- COX-1 normally produces prostaglandins that are gastroprotective. Thus, blocking it can lead to gastric ulcers/bleeds
- Arthrotec is a combination with misoprostol (to protect the stomach)
- Take with food or 8-oz of water
- May increase risk of cardiovascular thrombotic events, MI, and stroke
- Avoid in patients with cardiac history
- The flector patch and topical formulations are great as alternatives for these patients
- Flector patch- good for areas where local inflammatory relief is needed, but in patients who can’t take systemic NSAIDs
- medium and large joints (examples: shoulder, sacroiliac, knee, ankle, elbow)
- superficial painful tendons (examples: biceps tendon, DeQuervain’s, achilles)
- Arthrotec gel
- good for superficial, small joints and other small areas (ex: finger joints, tendonitis at wrist)
- Absolute contraindication: ASA allergy
Related Content:
Posted in Anti-inflammatories, Diclofenac - Voltaren, Medications, Miscellaneous
Posted on 21 August 2010. Tags: Aleve, anaprox, anaprox DS, naprelan, naprosyn, naproxen, naproxen sodium, Non-steroidal anti-inflammatory drug, pain
The following information is NOT meant to be used to treat yourself or patients
Generic name= Naproxen
Source: HealthSquare.com
Trade name = Aleve, Anaprox, Anaprox DS, Naprosyn, Naprelan
Class = anti-inflammatory
MOA
- Blocks cyclooxygenase (COX-1 & COX-2) and thus production of prostaglandins
Advantages
- Relatively inexpensive as generic
- Available OTC
- Least cardiovascular risk when using high-dose
Dosing
- 200, 220, 250, 275, 375, 500, 550-mg pills
- Comes in 200 and 220-mg over-the-counter [220 mg of naproxen sodium contains 200-mg naproxen]
- Typical dosing:
- 250-mg PO q6-8 hrs prn
- 500-mg PO q12 hrs
- Max dose: Do not exceed 1250-mg/day for more than a week
Note:
- COX-1 normally produces prostaglandins that are gastroprotective. Thus, blocking it can lead to gastric ulcers/bleeds
- Take with food or 8-oz of water
- May increase risk of cardiovascular thrombotic events, MI, and stroke
- Consider avoiding in patients with cardiac history
- The above warning is with all NSAIDs.
Keep in mind that naproxen at a high dose (500mg BID) has NOT been shown to increase the risk of cardiac and cerebral events
- Absolute contraindication: ASA allergy
- Naprelan is a controlled-release formulation
Related Content:
Posted in Anti-inflammatories, Medications, Miscellaneous, Naproxen - Aleve
Posted on 21 August 2010. Tags: advil, anti-inflammatory, Ibuprofen, motrin, Non-steroidal anti-inflammatory drug, Over-the-counter drug, pain
The following information is NOT meant to be used to treat yourself or patients
Generic name = Ibuprofen
Trade name = Advil, Motrin
Class = anti-inflammatory
MOA
- Blocks cyclooxygenase (COX-1 & COX-2) and thus production of prostaglandins
Advantages
- Relatively inexpensive as generic
- Available over-the-counter
Dosing
- 50, 100, 200, 300, 400, 600, 800-mg pills
- Comes in 200-mg pills over-the-counter
- For acute, short-term use, it is typically prescribed as 800-mg four times a day for a week
- Max dose: Do not exceed 800-mg/dose and 3200-mg/day for more than a week
Note:
- COX-1 normally produces prostaglandins that are gastroprotective. Thus, blocking it can lead to gastric ulcers/bleeds.
- Take with food or 8-oz of water
- May increase risk of cardiovascular thrombotic events, MI, and stroke
- Consider avoiding in patients with cardiac history
- Absolute contraindication: ASA allergy
- Use with caution in renal and liver impairment
Related Content:
Posted in Anti-inflammatories, Ibuprofen - Advil, Medications, Miscellaneous
