The following information is NOT meant to be used to treat yourself or patients
- Generic name = Ketorolac
Source: buyemp.com
- Trade name = Toradol
- Class = anti-inflammatory
- MOA
- Blocks cyclooxygenase (COX-1 & COX-2) and thus production of prostaglandins
- In vitro, ketorolac is the most COX-1 predominant NSAID (click here)
- Advantages
- When used IM or IV, it is the go-to NSAID for acute relief of severe pain
- Dosing
- Availability: 10-mg pills; 15, 30, 60-mg vials
- Typically given as a one-time IM/IV dose of 60-mg or 30-mg, or multi-dosed as 30-mg IM/IV q6h or 15-mg q6h
- If given as PO route, 10-mg PO q6h
- Max dose: Do not exceed 120-mg IV/IM per day, or 40-mg PO per day
- Max of 5 consecutive days
- Renal insufficiency dosing: 15-mg IV/IM q6h; do not exceed >60-mg/day
- Advanced renal impairment: contraindicated
- Note:
- COX-1 normally produces prostaglandins that are gastroprotective. Thus, blocking it can lead to gastric ulcers/bleeds
- Take with food or 8-oz of water
- May increase risk of cardiovascular thrombotic events, MI, and stroke
- Avoid in patients with cardiac history
- Absolute contraindication: ASA allergy
