Posted on 15 August 2010. Tags: carisoprodol, muscle relaxant, soma
The following information is NOT meant to be used to treat yourself or patients
- Generic name = Carisoprodol (kar eye soe proe’ dole)
- Trade name = Soma
- Class = muscle relaxant
- MOA
- Disadvantages
- May cause dependence because of the metabolite, meprobamate
- Dosing
- Strengths: 250, 350-mg
- 350 mg tid and qhs
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Posted in Medications, Muscle Relaxants
Posted on 15 August 2010. Tags: methocarbamol, muscle relaxant, robaxin
The following information is NOT meant to be used to treat yourself or patients
- Generic name = Methocarbamol
- Trade name = Robaxin
- Class = muscle relaxant
- MOA
- Unknown
- General CNS depression
- Advantages
- Relatively inexpensive
- IM/IV options
- Dosing
- 500, 750-mg pills
- 1500-2000 mg PO q6 hours for 2-3 days, then 1000 mg qid
- 500 mg PO qid in elderly (then titrate up as tolerated)
- Max dose: Do not exceed 3000-mg/day for more than 3 days
- Note:
- Avoid in renal dysfunction
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Posted in Medications, Muscle Relaxants
Posted on 15 August 2010. Tags: metaxalone, muscle relaxant, skelaxin
The following information is NOT meant to be used to treat yourself or patients
- Generic name = Metaxalone (me tax’ a lone)
Photo from Drug3k.com
- Trade name = Skelaxin
- Class = muscle relaxant
- MOA
- Thought to cause general CNS depression
- Dosing
- 800-mg pills
- 800 mg PO tid/qid
- Adequate trial period: 2 weeks
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Posted in Medications, Muscle Relaxants
Posted on 15 August 2010. Tags: chlorzoxazone, muscle relaxant, parafon forte
The following information is NOT meant to be used to treat yourself or patients
- Generic name = Chlorzoxazone (klor zox’ a zone)
Photo from Drug3k.com
- Trade name = Parafon Forte DSC
- Class = muscle relaxant
- MOA
- Dosing
- 250, 500-mg pills (generic)
- 250-500 mg tid/qid
- Max dose: 750 mg/dose
- Adequate trial period: 4 weeks
- Note:
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Posted in Medications, Muscle Relaxants
Posted on 15 August 2010. Tags: baclofen, lioresal, muscle relaxant
The following information is NOT meant to be used to treat yourself or patients
- Generic name = Baclofen
- Trade name = Lioresal
- Class = muscle relaxant
- MOA
- Centrally-acting
- Analog of GABA, but no evidence it works on the GABA system
- Advantages
- Great for spasticity in spinal cord injured, brain injured, and stroke patients
- Relatively inexpensive
- Disadvantages
- Dosing
- 10, 20-mg pills
- Starting dose: 5 mg PO tid
- Titrating: Increase by one 5-mg pill tid every 3 days until desired effect
- Max dose: 80 mg/day
- Adequate trial period: 4 weeks
- Note:
- MUST taper dose to discontinue
- Renal dosing
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Posted in Medications, Muscle Relaxants
Posted on 15 August 2010. Tags: muscle relaxant, tizanidine, zanaflex
The following information is NOT meant to be used to treat yourself or patients
- Generic name = Tizanidine
Photo from Drug3k.com
- Trade name = Zanaflex
- Class = muscle relaxant
- MOA
- Centrally-acting
- Binds to alpha-2 adrenergic receptors, increasing presynaptic motor neuron inhibition and reducing spasticity
- Advantages
- Disadvantages
- Can cause lowered blood pressure in spinal cord injured patients that already have a lowered baseline blood pressure
- Dosing
- Starting dose: 4 mg PO at night
- Titrating: Increase by one 4-mg pill every 2-3 days until desired effect
- Max dose: 12 mg/day
- Adequate trial period: 2-3 weeks
- Note:
- Renal dose if CrCl <25
- Hepatic dosing
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Posted in Medications, Muscle Relaxants
Posted on 15 August 2010. Tags: amrix, cyclobenzaprine, flexeril, muscle relaxant
The following information is NOT meant to be used to treat yourself or patients
- Generic name = Cyclobenzaprine
Photo from Drug3k.com
- Trade name = Flexeril, Amrix
- Class = muscle relaxant
- MOA
- Centrally-acting
- Thought to work at the brain stem, as opposed to spinal cord or neuromuscular junction.
- Structurally related to tricyclic antidepressants
- Advantages
- Relatively inexpensive generic – on many $4 plans
- Disadvantages
- Dosing
- Starting dose: 5 mg PO tid
- Max dose: 30 mg/day
- Adequate trial period: 2-3 weeks
- Note:
- 5 mg PO qd to start in elderly patients
- Amrix is an expensive extended-release formula; dosed daily
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Posted in Medications, Muscle Relaxants
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