Posted on 16 July 2010. Tags: fibromyalgia, Lyrica, neuropathic, Pregabalin
The following information is NOT meant to be used to treat yourself or patients
- Generic name = Pregabalin
Image from Drugs.com
- Trade name = Lyrica
- Class = antiepileptic
- MOA
- binds to voltage-gated calcium channels and inhibits neurotransmitter release
- Advantages
- Efficacious against many neuropathic pain conditions
- Linear pharmacokinetics = easier dosing
- Pain relief quicker than gabapentin
- FDA-approved for the treatment of fibromyalgia
- Dosing
- Starting dose: 150 mg/day (divided BID or TID)
- Titrating:
- Increase to 300 mg/day (divided BID/TID) after 3-7 days
- Then, increase by and extra 150 mg/day every 3-7 days
- Max dose: 600 mg/day (200mg TID or 300mg BID)
- Adequate trial period: 4 weeks
- Note: Decreased dose in patients with renal disease
- Most common adverse effects
- Peripheral edema and weight gain
- Ataxia, dizziness, somnolence, tremors
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Posted in Medications, Neuropathic
Posted on 16 July 2010. Tags: gabapentin, neurontin, neuropathic
The following information is NOT meant to be used to treat yourself or patients
- Generic name = Gabapentin
Image from Drugs.com
- Trade name = Neurontin
- Class = antiepileptic
- MOA
- binds to voltage-gated calcium channels and inhibits neurotransmitter release
- Advantages
- Relatively inexpensive
- Efficacious against many neuropathic pain conditions
- Disadvantages
- Nonlinear dosing
- Long titration period to get to effective dose – start low and titrate slowly
- Dosing
- Starting dose: 100-300mg at night
- Titrating: Increase by 100-300 mg TID every 1-7 days as tolerated
- Max dose: 3600 mg/day (max dose in clinical trials)
- Adequate trial period: 3-8 weeks for titration period, then 2-wks at max dose
- Note: Decreased dose in patients with renal disease
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Posted in Medications, Neuropathic
