The following information is NOT meant to be used to treat yourself or patients

  • Generic name = Gabapentin

    Image from Drugs.com
  • Trade name = Neurontin
  • Class = antiepileptic
  • MOA
    • binds to voltage-gated calcium channels and inhibits neurotransmitter release
  • Advantages
    • Relatively inexpensive
    • Efficacious against many neuropathic pain conditions
  • Disadvantages
    • Nonlinear dosing
    • Long titration period to get to effective dose – start low and titrate slowly
  • Dosing
    • Starting dose:  100-300mg at night
    • Titrating:  Increase by 100-300 mg TID  every 1-7 days as tolerated
    • Max dose:  3600 mg/day (max dose in clinical trials)
    • Adequate trial period:  3-8 weeks for titration period, then 2-wks at max dose
  • Note: Decreased dose in patients with renal disease

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