The following information is NOT meant to be used to treat yourself or patients

  • Generic name = Milnacipran
  • Trade name = Savella
  • Class = “antidepressant” (selective serotonin and norepinephrine reuptake inhibitors)
  • Advantages
    • Shown effective for fibromyalgia
  • Dosing
    • Fibromyalgia
      • Day 1: 12.5 mg x 1
      • Day 2-3: 12.5 mg BID
      • Day 4-7: 25 mg BID
      • Thereafter: 50 mg BID
      • Max dose:  100 mg BID
      • Adequate trial period:  4 weeks
  • Note: Decreased dose in patients with renal disease


  1. Milnacipran might be SNRI but it has no effect on pain conditions.
    I advice to update your page.
    Cochrane Database Syst Rev. 2015 Jul 6;(7):CD011789. doi: 10.1002/14651858.CD011789.
    Milnacipran for neuropathic pain in adults.
    There was no evidence to support the use of milnacipran to treat neuropathic pain conditions.


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